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You searched for: subject:"developmental biology"
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[texts]Dimorphic development in Streblospio benedicti: genetic analysis of morphological differences between larval types - Christina Zakas
The marine polychaete Streblospio benedicti exhibits two distinct larval types, making it a model for the study of developmental evolution. Females produce either large eggs or small ones, which develop into distinct lecithotrophic or planktotrophic larvae with concomitant morphological and life-history differences. Here, we investigate the inheritance of key morphological traits that distinguish the larval types...
Keywords: Developmental Biology
Downloads: 4
[texts]Stem cells in a colonial animal with localized growth zones - Stefan Siebert
Siphonophores (Hydrozoa) have unparalleled colony-level complexity, precision of organization, and functional specialization between zooids (i.e., the units that make up colonies). Previous work has shown that, unlike other colonial animals, most growth in siphonophores is restricted to one or two well-defined growth zones that are the sites of both elongation and zooid budding. To understand this unique growth at the cellular level, we characterize the distribution of interstitial stem cells (i...
Keywords: Developmental Biology
Downloads: 10
[texts]Drosophila embryogenesis scales uniformly across temperature and developmentally diverse species - Steven Gregory Kuntz
Temperature affects both the timing and outcome of animal development, but the detailed effects of temperature on the progress of early development have been poorly characterized. To determine the impact of temperature on the order and timing of events during Drosophila melanogaster embryogenesis, we used time-lapse imaging to track the progress of embryos from shortly after egg laying through hatching at seven precisely maintained temperatures between 17.5°C and 32.5°C...
Keywords: Developmental Biology
Downloads: 6
[texts]Gene co-expression modules underlying polymorphic and monomorphic zooids in the colonial hydrozoan, Hydractinia symbiolongicarpus - David C Plachetzki
Advances in sequencing technology have forced a quantitative revolution in Evolutionary Biology. One important feature of this renaissance is that comprehensive genomic resources can be obtained quickly for almost any taxon, thus speeding the development of new model organisms. Here we analyze 20 RNA-seq libraries from morphologically, sexually, and genetically distinct polyp types from the gonochoristic colonial hydrozoan,Hydractinia symbiolongicarpus (Cnidaria)...
Keywords: Developmental Biology
Downloads: 4
[texts]Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development - Jonathan Rodenfels
In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion...
Keywords: Developmental Biology
Downloads: 7
[texts]Comparison of the 3D organization of sperm and fibroblast genomes using the Hi-C approach - Nariman Battulin
The 3D organization of the genome is tightly connected to its biological function. The Hi-C approach was recently introduced as a method that can be used to identify higher-order chromatin interactions genome-wide. The aim of this study was to determine genome-wide chromatin interaction frequencies using the Hi-C approach in mouse sperm cells and embryonic fibroblasts. The obtained results demonstrated that the 3D genome organizations of sperm and fibroblast cells show a high degree of similarit...
Keywords: Developmental Biology
Downloads: 5
[texts]ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila - Emiliana Tognon
Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated cargoes into the internal luminal vesicles (ILVs) of the MVE. Drosophila genes encoding ESCRT-I, -II, -III components function in sorting signaling receptors, including Notch and the JAK/STAT signaling receptor Domeless...
Keywords: Developmental Biology
Downloads: 4
[texts]Generation of Aggregates of Mouse ES Cells that Show Symmetry Breaking, Polarisation and Emergent Collective Behaviour in vitro. - Peter Baillie-Johnson
Dissociated mouse embryonic stem (ES) cells were cultured to form aggregates in small volumes of basal medium in U-bottomed, non tissue-culture-treated 96-well plates and subsequently maintained in suspension culture. After growth for 48 hours, the aggregates are competent to respond to ubiquitous experimental signals which result in their symmetry-breaking and generation of defined polarised structures by 96 hours...
Keywords: Developmental Biology
Downloads: 2
[texts]Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition - Xiao-Yong Li
A conspicuous feature of early animal development is the lack of transcription from the embryonic genome, and it typically takes several hours to several days (depending on the species) until widespread transcription of the embryonic genome begins. Although this transition is ubiquitous, relatively little is known about how the shift from a transcriptionally quiescent to transcriptionally active genome is controlled...
Keywords: Developmental Biology
Downloads: 5
[texts]The methylome of the human frontal cortex across development - Andrew E Jaffe
DNA methylation (DNAm) plays an important role in epigenetic regulation of gene expression, orchestrating tissue differentiation and development during all stages of mammalian life. This epigenetic control is especially important in the human brain, with extremely dynamic gene expression during fetal and infant life, and becomes progressively more stable at later periods of development . We characterized the epigenetic state of the developing and aging human frontal cortex in post-mortem tissue ...
Keywords: Developmental Biology
Downloads: 9
[texts]An accelerated miRNA-based screen implicates Atf-3 in odorant receptor expression - Shreelatha Bhat
Large scale genetic screening is tedious and time-consuming. To address this problem, we propose a novel two-tiered screening system comprising an initial "pooling" screen that identifies miRNAs whose tissue-specific over-expression causes a phenotype of interest followed by a more focused secondary screen that uses gene-specific RNAi. As miRNAs inhibit translation or direct the destruction of their target mRNAs, any phenotype observed with miRNA over-expression can be attributed to the loss-of-...
Keywords: Developmental Biology
Downloads: 8
[texts]Lipoproteins carry endocannabinoids that inhibit the Hedgehog pathway - Helena Khaliullina
Hedgehog proteins are lipid-modified secreted signaling molecules that regulate tissue development and homeostasis. Lipids contained in circulating lipoproteins repress the Hedgehog signaling pathway in the absence of Hedgehog ligand, but the identity of these lipids is unknown. Here, using biochemical fractionation and lipid mass spectrometry, we identify these inhibitory lipids as endocannabinoids...
Keywords: Developmental Biology
Downloads: 9
[texts]Systematic Imaging Reveals Features of Localized mRNAs and Their Changing Subcellular Destinations in Development - Helena Jambor
The asymmetric distribution of cytoplasmic components by mRNA localization is critical for eukaryotic cells and affects large numbers of transcripts. How such global subcellular localization of mRNAs is regulated is still unknown. We combined transcriptomics and systematic imaging to determine tissue-specific expression and subcellular localizations of 5862 mRNAs during Drosophila oogenesis. While the transcriptome is stable and alternative splicing and polyadenylation is rare, cytoplasmic local...
Keywords: Developmental Biology
Downloads: 16
[texts]Orb prevents autophagy in the Drosophila germline through translational repression of Atg12 mRNA - Isabelle Busseau
Drosophila Orb, the homologue of vertebrate CPEB is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs. orb has also an essential function during early oogenesis which has not been addressed at the molecular level. Here, we show that orb prevents cell death during early stages of oogenesis, thus allowing oogenesis to progress. It does so through the repression of autophagy, by directly repressing, together with the CCR4 dead...
Keywords: Developmental Biology
Downloads: 14
[texts]Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-differentiation with iPSC Reprogramming Factors - Itay Maza
Recent reports have proposed a new paradigm for obtaining mature somatic cell types from fibroblasts without going through a pluripotent state, by briefly expressing canonical iPSC reprogramming factors Oct4, Sox2, Klf4, c-Myc (abbreviated as OSKM) in cells expanded in lineage differentiation promoting conditions. Here we apply genetic lineage tracing for endogenous Nanog locus and X chromosome reactivation during OSKM induced trans-differentiation, as these molecular events mark final stages fo...
Keywords: Developmental Biology
Downloads: 16
[texts]A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering in Drosophila - Xu Zhang
The development of CRISPR/Cas9 technologies promises a quantum leap in genome-engineering of model organisms. However, CRISPR-mediated gene targeting reports in Drosophila are still restricted to a few genes, use variable experimental conditions and vary in efficiency, questioning the universal applicability of the method. Here, we developed an efficient, two-step strategy to flexibly engineer the fly genome by combining CRISPR with recombinase-mediated cassette exchange (RMCE)...
Keywords: Developmental Biology
Downloads: 18
[texts]Zoologische Jahrbücher (Volume bd. 22)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 549
[texts]Zoologische Jahrbücher (Volume bd. 11)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 684
[texts]Zoologische Jahrbücher (Volume bd. 19)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 611
[texts]Zoologische Jahrbücher (Volume bd. 13)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 347
[texts]Zoologische Jahrbücher (Volume bd. 17)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 601
[texts]Zoologische Jahrbücher (Volume bd. 12)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 357
[texts]Zoologische Jahrbücher (Volume bd. 23)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 493
[texts]Zoologische Jahrbücher (Volume bd. 27)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 607
[texts]Zoologische Jahrbücher (Volume bd. 30)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 655
[texts]Zoologische Jahrbücher (Volume bd. 18)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 420
[texts]Zoologische Jahrbücher (Volume bd. 4)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 268
[texts]Zoologische Jahrbücher (Volume bd. 40)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 631
[texts]Zoologische Jahrbücher (Volume bd. 10)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 433
[texts]Zoologische Jahrbücher (Volume bd. 43)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 876
[texts]Zoologische Jahrbücher (Volume bd. 3)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 312
[texts]Zoologische Jahrbücher (Volume bd. 24)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 575
[texts][ Lewis Wolpert] Principles Of Development ( Second ( Book Fi.org)
developmental biology
Keywords: developmental biology; genetics; embryology
Downloads: 167
[texts]Zoologische Jahrbücher (Volume bd. 25)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 498
[texts]Zoologische Jahrbücher (Volume bd. 29)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 547
[texts]Zoologische Jahrbücher (Volume bd. 41)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 600
[texts]Zoologische Jahrbücher (Volume Index = Generalregister bd. 1-20)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 1,599
[texts]Zoologische Jahrbücher (Volume bd.5)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 411
[texts]Zoologische Jahrbücher (Volume bd. 16)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 379
[texts]Zoologische Jahrbücher (Volume bd. 26)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 329
[texts]Zoologische Jahrbücher (Volume bd. 20)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 319
[texts]Zoologische Jahrbücher (Volume bd. 5)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 372
[texts]Zoologische Jahrbücher (Volume bd. 14)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 307
[texts]Zoologische Jahrbücher (Volume bd. 6)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 307
[texts]Zoologische Jahrbücher (Volume bd. 33)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 401
[texts]Zoologische Jahrbücher (Volume bd. 42)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 490
[texts]Zoologische Jahrbücher (Volume v. 35 1912/13)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 293
[texts]Zoologische Jahrbücher (Volume bd.23)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 587
[texts]Zoologische Jahrbücher (Volume bd. 8)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 491
[texts]Zoologische Jahrbücher (Volume bd. 38)
Description based on: Bd. 68, Heft 1 (28. Okt. 1942); title from cover
Keywords: Zoology; Anatomy; Developmental biology
Downloads: 526
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